The Cardiology Department at CMC comprises four units collectively. The department manages a busy outpatient clinic, serving over 300 patients daily.  rehabilitation center.

The Cardiothoracic department at CMC is distinguished as the oldest of its kind in the country. The department is well-equipped to perform a wide range of surgical procedures, including coronary artery bypass surgeries, valve replacements, and surgeries for congenital heart abnormalities. The department's expertise extends to several complex procedures, such as lead extraction, VT ablation requiring an intercostal window, epicardial left ventricular pacemaker lead placement in unfavourable coronary sinus anatomy, and pacemaker implantation in neonates.

The sub-specialty of Cardio-thoracic imaging has qualified and trained cardiothoracic radiologists, to cater to the large volume of cardiothoracic cross-sectional imaging. Dedicated imaging of the heart and coronary arteries including CT coronary angiogram, CT cardiac for various congenital and acquired heart diseases, preplanning CT for TAVI, MRI cardiac studies for both congenital and acquired conditions including viability, adenosine stress test, and cardiomyopathies. Routine and advanced sequences including phase contrast flow analysis, MR angiogram, late gadolinium enhancement, T2* mapping, T1, T2, and ECV mapping are also performed. In the domain of thorax imaging, HRCT thorax, Contrast-enhanced CT thorax, CT pulmonary angiogram, and MRI thorax including cine MRI are routinely performed.

The Department of Physiology has a strong history and background in cardiovascular research. The research interest of the faculty in this field includes studies on contractility of the heart, pace-making mechanisms, and heart rate variability. Various facilities are available for studying cardiac function in cells, tissues, isolated hearts (Langendorff perfusion), small animals like rats, and humans. Facilities include a patch clamp facility to record ionic currents and action potentials from isolated cardiac and pacemaker cells.  Calcium imaging with confocal microscopy is also done in these cells using fluorescent probes like Fluo-4. A human physiology laboratory is available for studying exercise physiology, heart rate variability, and other tests to assess the autonomic nervous system. Recently the department has been involved in developing and validating a new blood pressure measuring device.

The Department of Clinical Genetics was initiated in 2007 to provide comprehensive consultations, genetic counseling, and prenatal diagnostic services to patients and families with a diverse array of genetic conditions. Over the past decade, the department has expanded its services to the Cardiology department to perform genetic profiling of inherited cardiomyopathies, rhythm disorders, and various syndromes through the use of conventional molecular techniques and Next-generation sequencing, utilizing advanced Bioinformatics tools. Continued research in these areas is contributing to improved patient management and care.

The department of Bioengineering has been working in the area of cardiovascular physiology, in collaboration with the department of Physiology and the department of Cardiology.In this collaboration, the contribution of Bioengineering has been in the development of analytical models to interpret electrophysiological and mechanophysiological data, design of measurement instruments, algorithms for analysis, etc. The development of a 3D cardiac vector calculator from ECG data, a 3D heart vector simulator with ECG lead calculations, and an invasive blood pressure measurement model are some of the analytical models developed in Bioengineering. Instrumentation, embedded hardware, and software, for blood pressure measurement are some of the electronic and digital devices developed in Bioengineering.

The department of Nuclear Medicine specializes in diagnostic tests and treatments using radioactive materials. Nuclear medicine imaging is non-invasive and unique, as it offers both integrations of structural 

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Effectively managing sleep apnoea and Sarcoidosis typically involves close collaboration between the Electrophysiology (EP) division and Pulmonary Medicine, to optimize patient care and treatment.